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CHANGING HUMAN BEINGS BY MRT IS MISLEADING AND NOT SCIENTIFIC*

Ke-Hui Cui M.D., Ph.D.

Savannah, Georgia, 31405, U.S.A.

Dec. 19, 2016

Email: khcui72@hereditics.net

*Comment for "Expert panel approve cautious use of mitochondrial donation in the UK", ivf.net, Dec. 5,  2016.

Human beings are superior to animals depends on the superiority of heredity of human genes, which is originated by natural (or “green”) selection in million years rather by artificial manufacture. Genetic diseases are the kind of natural selection to abandon those abnormal results from gene mutation or chromosomal abnormalities and keep human beings to be healthy. New gene mutation and new chromosomal abnormalities will continuously happen, including mitochrondrial diseases. Preimplantaion genetic diagnoses (PGD) and prenatal diagnoses are the best tools developed by us to prevent genetic diseases without changing human beings. Using mitochondrial replacement therapy (MRT), gene correction (CRISPR, etc.), stem cell or artificial germline to produce artificial human beings is misleading and not scientific, because they will stop the natural development of human beings. To produce artificial human beings (i.e. sub-human beings or “three parent’s offspring, or offspring from gene-transfer germline) is not ethical, not humanistic. It will greatly ruin human beings. In Second World War, Adolf Hitler and Nazi "eugenics" could not ruin human beings, because people in the world recognized that was not correct and opposed them. However, the recent artificial human beings can ruin human beings. So many pseudoscientists, money-chasing media and bureaucratic law-makers and officials are keen to the subject of artificial human beings and MRT. It is shame that they claim that MRT “gives women who have mitochondrial DNA mutations reproductive choice, and … delighted for them.”

 

MRT is not scientific. The facts and reasons are:

1. The creators of MRT did not know the basic theory of cell biology. A lot of mitochrondrial diseases are produced by the both cytoplasm mitochrondrial DNA and nuclear (chromosomal) DNA, rather than cytoplasm mitochrondrial DNA only. Nuclear DNA also regulate cytoplasm mitochrondrial DNA. MRT can not solve this basic biological problem.

2. MRT techniques are not safe. All of the nuclear chromosomes or spindle chromosomes are binding to the microtubules anchored on the cell membrane. The spindle or pronuclear transfer techniques should tear and break the microtubules for transfer. The torn microtubules can not connect to the original position with original length, which will lead to chromosomal abnormalities or gene abnormalities, and produce abnormal fetus or babies. John Zhang produced five pregnancies in China in 2003 and all five of them were stillbirth. And until now, John Zhang did not have any knowledge and ability to analyze what was the reason of those still birth.

3. The "health" report of 17 teenagers from MRT performed by Jacques Cohen showed the results were not healthy. Three child’s data was absent. Others showed more immune deficiencies and neuropathy problem than usual incident rate from general population. The fact showed: It is not possible to obtain detail data about all of the offspring for further scientific results. Most those parents wish to hide the fact of three parent from their children. Also, those children did not be marked on the birth certificate that their genes containing three parent’s genes, which is totally not responsible for the further health of human being. All of their procedures are not scientific and not ethical.

4. When mother has mitochrondrial disease, the nuclear DNA of her oocytes are lack of energy to get normal development, which will lead to the oocytes containing abnormal methylation or leading to earlier degenerated. To use this kind of ill or partly ill spindle DNA or nuclear DNA from the oocytes to produce babies will get unhealthy child. Not healthy oocytes can only produce non-healthy babies. To use donor’s oocytes is much easier and healthier.

5. Why do these pseudoscientists knowing that “the technique (of MRT) is currently imperfect” and still going on clinical practice so in a hurry? For the parent to get a healthy child? It is logically wrong. The fact is: They use MRT to be a billboard to show people how advanced techniques and research the country and their institute have. Their aim is for money, trillions dollars. This is a kind of “nationalism”. UK, U.S. and China are all competing on it. It is a negative competition. Propaganda is loud and action is very, very slowly, trying not break the red line of heredity of human being. It is like walking on an iron line. Who perform MRT on the patient first, or who will break the red line to challenge natural human being (changing “green” human beings to be sub-human beings) first, who will be low intelligence quotient (IQ) and turning to be the enemy of our human beings. John Zhang got it first. He talked nonsense to New China news agency that MRT is a new generation of IVF techniques and he will further perform a new bigger program. What is his new program? OvaSciences in Wall Street share market has outlined as mitochondrial Augment Program (See wetsite OvaSciences for detail), which suggested artificially extracted mitochondria should be injected into every eggs to obtain human babies. That is to make every family and every child to be sub-human beings. Just by talking, OvaSciences has collected billions dollars in Nasdaq share market in about four years. If Human Fertilisation and Embryology Authority (HFEA) approve MRT for clinical use in UK, it will mean HFEA formally declare the start of producing three parent human beings. It is similarly as to declare a formal war to our natural human beings. Money will make everything changing to some degree that we will not foresee at the time being. They will control medical field, media, congress man, law maker and legislation. Now they have control British congress and HFEA already. The war without gun fight would last several generations to several centuries. The new society of sub-human beings could be formed and our human beings would be suppressed. Thus, MRT is totally not scientific, but political and money-chasing. It is a new kind of corruption in modern science.

 

To change human beings in heredity should get approval from all the people in the world, rather than HFEA or pseudoscientists. Any malpractice to change human beings in heredity should be punished by law.

 

Please also read:

 

1. “HUMAN BEINGS SHOULD NOT BE CHANGED IN HEREDITY” published on ivf.net 18 October 2016 comment for “Mitochondrial replacement therapy and the welfare of the child” response on 02 November 2016.

 

2. “Fact Sheet 2. Re: Not Suitability To Use Artificially Created, Modified Or Reprogrammed Human Eggs (Or Sperm) To Produce Babies” (Letter to FDA on March 22, 2013) published on ivf.net 25 October, 2016 comment for “Functional mouse eggs made from artificial stem cells” response on 11 November 2016.

3. “CHANGING HUMAN BEINGS IN HEREDITY IS MISLEADING AND INFAMOUS” published on ivf.net 01 November 2016 comment for “ ‘Three-person babies’ grow up into healthy teenagers” response on 07 November 2016.

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